FRIEDEWALD FORMULA SIGNIFICANTLY UNDERESTIMATES LDL CHOLESTEROL COMPARED TO PREPARATIVE ULTRACENTRIFUGATION BELOW 70 MG/DL LEADING TO OVERESTIMATION OF THE LDL CHOLESTEROL REDUCTION FOR NEW DRUGS IN DEVELOPMENT
نویسندگان
چکیده
منابع مشابه
Comparison of LDL- Cholesterol Enzymatic Method with Friedewald’s Formula
Abstract Background and Objectives: Concentration low-density lipoprotein (LDL) is one of the strongest indicators of atherosclerosis and predicts the diagnosis of cardiovascular diseases. LDL measurement accuracy is very important. LDL can be measured directly, such as enzymatic and nephelometry methods or can be calculated using Friedewald...
متن کاملUse of the Friedewald formula to estimate LDL-cholesterol in patients with chronic renal failure on dialysis.
Increased plasma cholesterol, particularly that portion associated with LDL, is an established risk factor for coronary heart disease [1, 2]. As a consequence, it is widely recommended [3] that LDL-cholesterol be determined in individuals with increased total cholesterol. Because isolation of the LDL fraction requires ultracentrifugation, a technique not generally available in service laborator...
متن کاملSeven direct methods for measuring HDL and LDL cholesterol compared with ultracentrifugation reference measurement procedures.
BACKGROUND Methods from 7 manufacturers and 1 distributor for directly measuring HDL cholesterol (C) and LDL-C were evaluated for imprecision, trueness, total error, and specificity in nonfrozen serum samples. METHODS We performed each direct method according to the manufacturer's instructions, using a Roche/Hitachi 917 analyzer, and compared the results with those obtained with reference mea...
متن کاملComparison of LDL-cholesterol direct measurement with the estimate using the Friedewald formula in a sample of 10,664 patients.
OBJECTIVE To compare direct measurement of LDL-cholesterol (LDL-C) determined by a homogeneous method with LDL-cholesterol estimation determined by the Friedewald formula in a large heterogeneous population. METHODS The measurements of total cholesterol (TC) and triglycerides (TG) were performed using traditional enzymatic methods. The measurements of HDL-C and LDL-C were performed using dire...
متن کاملcomparison of ldl- cholesterol enzymatic method with friedewald’s formula
abstract background and objectives: concentration low-density lipoprotein (ldl) is one of the strongest indicators of atherosclerosis and predicts the diagnosis of cardiovascular diseases. ldl measurement accuracy is very important. ldl can be measured directly, such as enzymatic and nephelometry methods or can be calculated using friedewald's formula. despite the development of e...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2014
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(14)61457-1